Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor
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, 1372 (2013); 342 Science et al. Nicolas Rohner for Loss of Eyes in Cavefish Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): January 16, 2014 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/342/6164/1372.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2013/12/11/342.6164.1372.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/342/6164/1372.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/342/6164/1372.full.html#ref-list-1 , 5 of which can be accessed free: cites 29 articles This article
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Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ul...
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The relationship between robustness and evolvability is a long-standing question in evolution. Heat shock protein 90 (HSP90), a molecular chaperone, has been identified as a potential capacitor for evolution, since it allows for the accumulation and release of cryptic genetic variation, and also for the regulation of novel genetic variation through transposon activity. However, to date, it is u...
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